Prostate cancer cells like big fish and big meat like you! A study showed that saturated fat intake in patients with prostate cancer can induce reprogramming of the cells, leading to accelerated cancer progression and an increased risk of death.
Overexpression of MYC can reshape the cellular program and enhance unique transcription characteristics; it can induce malignant properties in normal cells and promote the growth of cancer cells. We simulated overexpression of MYC and found that saturated fat intake worsens prostate cancer.
In this study, the researchers conducted daily food questionnaires on healthy follow-up patients and patients in the doctor’s study cohort. A total of 319 people were classified according to the amount of fat intake and the type of fat consumed. Combining diet and gene expression data found that animal fats, especially saturated fats, can lead to overexpression of MYC. This conjecture was validated in a mouse prostate cancer model experiment.
The data shows that regardless of the patient’s age or time of diagnosis, patients with the highest saturated fat intake are 4 times more likely to die from prostate cancer than those with the lowest intake, even after adjusting for the impact of prostate cancer malignancy staging. There is still meaning. Given that obesity is also a high risk factor for prostate cancer, and obesity is closely related to a high-fat diet, they ruled out the impact of body mass index. Even if the obesity factor is eliminated, people with high MYC expression are still three times more likely to die from prostate cancer than ordinary people.
With this discovery, we can identify more aggressive and fatal high-risk cancers; on the other hand, this study also confirms dietary interventions for prostate cancer, including reducing animal fats, especially saturated fat in early prostate cancer patients Ingestion may reduce or delay the risk of disease progression. It is worth noting that some people who do not have MYC gene amplification may also benefit from therapies that target MYC. Knowing the patient’s diet patterns and physical activity levels, clinicians can develop specific interventions to reduce the likelihood of prostate cancer developing into a fatal disease.